JOURNAL OF EVIDENCE BASED MEDICINE AND HEALTHCARE

Table of Contents

2018 Month : February Volume : 5 Issue : 10 Page : 878-881

SEMI-QUANTITATIVE PROCALCITONIN KIT FOR EVALUATING SEVERITY AND PREDICTING MORTALITY IN SEPSIS

Narender Katakam1, Sridevi Durgaraju2

Corresponding Author:
Dr. Narender Katakam,
House No.11-26-105, Katakam Clinic,
Kothawada, Warangal- 506002, Telangana.
E-mail: narendermd@gmail.com
DOI: 10.18410/jebmh/2018/178

ABSTRACT
BACKGROUND
Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. Sepsis is caused by an immune response triggered by an infection. Most commonly, the infection is bacterial, but it may also be from fungi, viruses, or parasites. This study evaluates the semi-quantitative pro-calcitonin kit for evaluating sepsis severity and determines the mortality in affected patients.

MATERIALS AND METHODS
This study was a prospective study which was conducted in the Department of General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, Telangana conducted from July 2015 to September 2016.

RESULTS
The DIC, SOFA and APACHE II scores were found to be significant i.e. have P<0.01 between group A and C and between group B and C. There was a significantly higher procalcitonin concentrations in patients with severe sepsis and septic shock than in those patients with less severe disease. It was observed that there was an upward trend in pro-calcitonin concentrations in patients with septic shock. In the three group, a significant (P< 0.01) difference was observed with regard to numbers of patients and rates of severe sepsis, septic shock, DIC, and mortality.

CONCLUSION
For detecting the disease severity early in sepsis patients, semi-quantitative pro-calcitonin concentration testing can be used as a useful tool. It may also predict the mortality in septic patients at an early stage.

KEYWORDS
Sepsis, Disseminated Intravascular Coagulation, Acute Physiological and Chronic Health Evaluation, Sequential Organ Failure Assessment.