JOURNAL OF EVIDENCE BASED MEDICINE AND HEALTHCARE

Table of Contents

2018 Month : March Volume : 5 Issue : 11 Page : 991-996

A COMPARATIVE STUDY OF DEXMEDETOMIDINE AND CLONIDINE IN EPIDURAL ANAESTHESIA WITH ROPIVACAINE FOR LOWER ABDOMINAL AND LOWER LIMB SURGERY

Olugumanu Srinivas Kumar1, Pradeep Hosagaoudar2, Y. V. Murali3, Sreenivas Reddy M4

Corresponding Author:
Dr. Pradeep Hosagoudar,
Associate Professor, Department of Anaesthesiology,
PES Institute of Medical Sciences and Research,
Kuppam - 517425, Andhra Pradesh.
E-mail: drpaddy82@gmail.com
DOI: 10.18410/jebmh/2018/204

ABSTRACT
BACKGROUND
Epidural anaesthesia using Inj. Ropivacaine results in an effective anaesthesia and postoperative analgesia and addition of adjuvants would be advantageous. Clonidine and dexmedetomidine are α2-agonists used as adjuvants in epidural anaesthesia. Aim of our study was to compare Inj. Dexmedetomidine and Inj. Clonidine added to epidural ropivacaine with respect haemodynamic parameters- heart rate, systolic blood pressure, diastolic blood pressure, motor blockade and sedations scores in patients undergoing lower abdominal and lower limb surgeries.

MATERIALS AND METHODS
This prospective, randomized, double blind study involved 60 patients of ASA-I, II who were categorized into two groups- Group-RD (n=30) received 1µ/kg Inj. Dexmedetomidine and Group-RC (n=30) received 1 µg/kg Inj. Clonidine. Patients in both groups received 17 ml of Inj. Ropivacaine epidurally. Patients were assessed for sensory block of T10 level, heart rate, systolic blood pressure and diastolic blood pressure, motor blockade using modified Bromage score and sedation score using Ramsay sedation scale.

RESULTS
Epidural anaesthesia using ropivacaine and adjuvants either clonidine or dexmedetomidine resulted in good sensory analgesia. Haemodynamic parameters with respect to heart rate, systolic blood pressure and diastolic blood pressure were similar between the two groups and were statistically not significant (p > 0.05). Sedation scores and modified Bromage scores were statistically significant (p < 0.05) for brief intervals of time.

CONCLUSION
Clonidine and Dexmedetomidine when used as adjuvants to epidural ropivacaine result in stable haemodynamics. Their sedation and motor blockade effects are comparable without significant adverse effects.

KEYWORDS
Clonidine, Dexmedetomidine, Epidural Anaesthesia, Ropivacaine.