JOURNAL OF EVIDENCE BASED MEDICINE AND HEALTHCARE

Table of Contents

2018 Month : August Volume : 5 Issue : 33 Page : 2436-2438

COMPARISON OF PREDISPOSING FACTORS FOR THE DEVELOPMENT OF DRUG SUSCEPTIBLE AND DRUG RESISTANT PULMONARY TB RE-TREATMENT CASES

Balaji Ganapathi Kothandapani1, Sridhar Rathinam2, Vinod Kumar Viswanathan3, Kumar Satagopan4

Corresponding Author:
Dr. V. Vinod Kumar,
#77, GST Road, Tambaram Sanatorium,
Chennai- 600047.
E-mail: drvinodkumar76@gmail.com
DOI: 10.18410/jebmh/2018/502

ABSTRACT
BACKGROUND
At present, multidrug resistant (MDR-TB) is a challenge in global efforts to prevent and control tuberculosis. WHO reports estimate that 3.5% of newly diagnosed TB patients and 20.5% of previously treated patients had MDR-TB.1,2 Known risk factors for emergence of MDR TB include age, sex, number of times exposed to ATT treatment, HIV status and alcoholism.3,4,5
The aim of the study is to compare the predisposing factors towards the development of drug susceptible and drug resistant PTB among retreatment cases.

MATERIALS AND METHODS
This study was conducted among 300 retreatment pulmonary tuberculosis patients attending Government Hospital of Thoracic Medicine, Tambaram sanatorium from 2016-18. 150 patients each of drug (Rifampicin) sensitive and drug resistant (Rifampicin) TB diagnosed by CBNAAT were selected by simple random sampling. Detailed data including demographic particulars, treatment history, personal history, HIV status were collected using a standardised questionnaire and the results were statistically analysed.

RESULTS
Age >45 years, male sex, lower educational status, history of treatment interruption, HIV positive status, smoking and alcoholism were found to have a statistically significant correlation with the development of drug resistant TB.

CONCLUSION
Several factors contribute to the development of drug resistant tuberculosis. If the goal of eliminating TB by 2025 is to be achieved, the focus should be on the prevention of development of drug resistant TB by ensuring that patients take full course of treatment properly the first time. Knowledge of factors associated with drug resistant TB will help us to plan better intervention strategies such as pretreatment counselling, smoking and alcohol cessation clinic.

KEYWORDS
Drug Resistant TB, Drug Susceptible TB, MDR TB, Contributing Factors.