JOURNAL OF EVIDENCE BASED MEDICINE AND HEALTHCARE

Table of Contents

2018 Month : October Volume : 5 Issue : 41 Page : 2918-2921

A COMPARATIVE STUDY OF THE EFFECT OF ADDITION OF MAGNESIUM SULPHATE TO HYPERBARIC BUPIVACAINE IN PATIENTS UNDERGOING LOWER ABDOMINAL SURGERIES

Anshu1, Rajesh Angral2, Heena Gupta3, Amit Kumar4

Corresponding Author:
Dr. Anshu,
C/o. Shiva Traders,
Sidco Chowk, Near Canal Crossing,
National Highway, Bari Brahmana Dist.- 181133,
Samba.
E-mail: dranshuroymd@gmail.com
DOI: 10.18410/jebmh/2018/596

ABSTRACT
BACKGROUND
Magnesium is a noncompetitive blocker of N-Methyl-D-Aspartate (NMDA) receptor with anti-nociceptive effects. Recently it has gained popularity as an adjuvant in spinal anaesthesia. The addition of intrathecal magnesium sulphate to hyperbaric bupivacaine prolongs the duration of analgesia. In this prospective, randomized, double-blind study, we investigated the effect of adding intrathecal magnesium sulphate to bupivacaine in spinal anaesthesia for lower abdominal surgeries.

MATERIALS AND METHODS
Sixty ASA I or II adult patients of either sex undergoing lower abdominal surgeries were recruited. They were randomly allocated into two groups- Group M received intrathecal 15 mg bupivacaine (0.5% hyperbaric solution) combined with 0.5 mL of 10% MgSO4; Group B received 15 mg bupivacaine (0.5% hyperbaric solution) combined with 0.5 mL of normal saline. We evaluated the onset of sensory and motor block, the duration of sensory and motor blockade and duration of spinal anaesthesia.

RESULTS
Onset of sensory and motor block was significantly shorter in Group B (2.06±0.79, 3.03±0.65 min) than Group M (4.84±2.24, 7.38±1.14 min).The duration of sensory block was significantly higher in Group M (220.78±9.4 min) than in Group B (165.78±17.6) The mean duration for complete motor recovery was maximum in Group M (271.44±34.72 min) than in Group B (180±18.41 min). Duration of analgesia was also longer in Group M (340.62±15.4 min) than with Group B (234.6±27.14 min) which was statistically significant (P<0.05).

CONCLUSION
In patients undergoing lower abdominal surgery, the addition of intrathecal magnesium sulphate to spinal anaesthesia induced by bupivacaine delayed the onset of both sensory and motor blockade, but improved the quality and the duration of postoperative analgesia.

KEYWORDS
Adjuvant, Magnesium Sulphate, Bupivacaine, Intrathecal, NMDA Receptor.