JOURNAL OF EVIDENCE BASED MEDICINE AND HEALTHCARE

Table of Contents

2018 Month : November Volume : 5 Issue : 45 Page : 3160-3163

STUDY OF CK-MB IN NEONATAL ASPHYXIA AND ITS CORRELATION WITH DIFFERENT STAGES OF HYPOXIC ISCHAEMIC ENCEPHALOPATHY

Prachi Paliwal1, Deepasha Shahi Bagzai2, Meena Varma3, Swati Mulye4, Rajesh Kumar Srivastava5, Manoj Narayan Paliwal6, Darshana Jain7

Corresponding Author:
Dr. Deepasha Shahi Bagzai,
C/o. Sonu Saluja, No. 35,
Golden Palace, Near Basantpuri,
AB Road, Indore- 452012, Madhya Pradesh.
E-mail: semu_jayu@yahoo.co.in
DOI: 10.18410/jebmh/2018/643

ABSTRACT
BACKGROUND
Perinatal asphyxia is one of the leading causes of neonatal morbidity and mortality in the neonatal intensive care unit. Hypoxic ischaemic encephalopathy (HIE) refers to clinically observable CNS dysfunction associated with perinatal asphyxia.
The aim of the study is to determine the serum levels of cardiac marker (CK-MB) in newborns with perinatal asphyxia and its relationship with different stages of HIE.

MATERIALS AND METHODS
We have measured the serum concentration of CK-MB by Creatine Kinase method in 100 asphyxiated newborns (cases) and 100 healthy newborns (control group). Blood samples were collected on day 1 and day 3 of life in all newborns.

RESULTS
The mean serum values of CK-MB were found to be decreased on day 3 in asphyxiated neonates and a negative correlation was seen between day 1 and 3 for CK-MB. The mean values of CK-MB were decreased in different stages of HIE on day 3 as compared to day 1 and a negative correlation was observed between day 1 and day 3 for CK-MB in no HIE, HIE I, HIE II and HIE III stages.

CONCLUSION
We conclude that serum CK-MB concentrations were increased considerably after birth asphyxia, and the increase is associated with the severity of HIE with a poorer outcome.

KEYWORDS
Hypoxic-Ischemic Encephalopathy, Creatine Kinase.