JOURNAL OF EVIDENCE BASED MEDICINE AND HEALTHCARE

Table of Contents

2019 Month : January Volume : 6 Issue : 1 Page : 1-8

COMPARATIVE STUDY OF OVARIAN RESERVE TESTS AND OVARIAN RESPONSE TO CONTROLLED OVARIAN STIMULATION IN IVF.

Karunakaran Sandeep1, Srinivas Sangisapu2

Corresponding Author:
Dr. Srinivas Sangisapu,
#42, Revati, Robert Road,
Near RC Church, Colaba,
Mumbai- 400005, Maharashtra.
E-mail: sangisapu.srinivas@rediff.com
sangisapu.srinivas@gmail.com
DOI: 10.18410/jebmh/2019/1

ABSTRACT
BACKGROUND
Controlled ovarian stimulation (COS) and optimum retrieval of fertilizable oocytes is crucial for IVF success. Ovarian response to COS is related to ovarian reserve (OR)- size of primordial follicular pool capable of maturing in the presence of gonadotrophins. There is a temporal fall in follicular pool from embryonic life onwards. The quest for ideal ovarian reserve test (ORT) resulted in several markers to measure ovarian response singly or in combination increasing the cost. The present study is a comparative evaluation of these tests with a view to ascertain the single most suitable test for ovarian response.
The aim of the study is to compare and evaluate various ORTs with ovarian response and oocyte retrieval.
The Objective of the study is to measure the hormonal and sonographic ovarian reserve markers and to evaluate which measure amongst them is superior in assessing the ovarian response and oocyte retrieval.

MATERIALS AND METHODS
Single centre retrospective cohort study of 183 women planned for first fresh cycle IVF with COS by GnRH agonist long protocol. Antral follicle count (AFC) and basal hormonal assay for FSH, LH, Oestradiol (E2), Inhibin-B and AMH were compared and evaluated for ovarian response and oocyte retrieval.

RESULTS
Serum AMH levels and Total AFC are significantly (p<0.001) lower in poor responders which is further confirmed by multivariate regression analysis (<0.05). It also shows that both AMH and AFC are significant (p<0.001) predictors of number of oocytes retrieved.

CONCLUSION
Serum AMH and Antral Follicular Count (AFC) are equally significant predictors of ovarian response and number of oocytes retrieved.

KEYWORDS
Ovarian Reserve Test (ORT), AFC, AMH, Predictors of Ovarian Response, Oocyte Retrieval.