JOURNAL OF EVIDENCE BASED MEDICINE AND HEALTHCARE

Table of Contents

2019 Month : February Volume : 6 Issue : 5 Page : 304-310

A STUDY ON ADDITIVE ASSOCIATION OF LIPOPROTEIN (A) AND HOMOCYSTEINE IN ACUTE ST SEGMENT ELEVATION MYOCARDIAL INFARCTION.

Mohanraj Perumal1, Anbazhagan Govindaraj2

Corresponding Author:
Dr. P. Mohanraj,
#13/5, Thiruvalluvar Street,
Little Kanchipuram,
Kanchipuram, Tamil Nadu- 631501.
E-mail: mohandr1976@gmail.com
DOI: 10.18410/jebmh/2019/62

ABSTRACT
BACKGROUND
Prevalence of Coronary Artery Disease (CAD) is increasing in India. Acute myocardial infarction has very high morbidity and mortality, hence economically a big burden. However, established risk factors alone do not explain this excess of coronary artery disease, emerging risk factors like Hyperhomocysteinaemia and Lipoprotein (a) have been recognized as independent risk factors for CAD in many retrospective case control studies. This study is done to analyse plasma homocysteine and lipoprotein(a) levels in patients admitted to the hospital with Coronary Heart Disease for its role and its relation to other known risk factors.

MATERIALS AND METHODS
This study was conducted in 50 patients of acute ST elevation myocardial infarction (STEMI). Patients visiting OPD and inpatients in the department of medicine, Meenakshi Medical College Hospital and Research Institute during the period of February 2018 to August 2018 were included in the study. This study also included 50 people as control group. Patients were screened to look for traditional risk factors, and the homocysteine and lipoprotein(a) levels were documented.

RESULTS
When the association of both elevated lipoprotein (a) and homocysteine were compared with case and control group, it was seen that there is a high statistical significance with p-value of <0.001 and the relative risk is 25.6

CONCLUSION
The association of elevated lipoprotein(a) and hyperhomocysteinaemia with STEMI were significant. Hyperhomocysteinaemia seems to have the stronger association with STEMI than elevated Lipoprotein(a). The relative risk of STEMI was more when both homocysteine and lipoprotein(a) were elevated than the individual relative risk added together.

KEYWORDS
Homocysteine; Lipoprotein (a); Acute ST Elevation Myocardial Infarction.