JOURNAL OF EVIDENCE BASED MEDICINE AND HEALTHCARE

Table of Contents

2019 Month : March Volume : 6 Issue : 9 Page : 697-701

A CLINICAL PROFILE OF NON-MOTOR SYMPTOMS IN PARKINSON’S DISEASE- HOSPITAL BASED OBSERVATIONAL STUDY

Amit Govind Kamat1, Amruta C2

Corresponding Author:
Dr. Amruta C,
Assistant Professor,
Department of Obstetrics and Gynaecology,
Karwar Institute of Medical Sciences,
Karwar, Karnataka.
E-mail: dramitkamat@gmail.com
DOI: 10.18410/jebmh/2019/145

ABSTRACT
BACKGROUND
Parkinson’s disease (PD) is the second most common neurodegenerative disorder. It is a result of degeneration of the substantia nigra, pars compacta with dysfunction of dopaminergic nigrostriatal pathway. The three cardinal signs of Parkinson disease are resting tremor, rigidity, and bradykinesia. Apart from these, non-motor symptoms (NMS)s substantially contribute to patient’s quality of life and are a frequent cause of hospitalization which are poorly recognized and inadequately treated.
The objectives of the study are- 1) To find out the prevalence of non-motor symptoms in participants and 2) To classify and analyse the non-motor symptoms in them on the basis of system involvement.

MATERIALS AND METHODS
This is a hospital based observational study conducted on 50 patients of Parkinsonism over a period of 1 year. Parkinson’s disease was confirmed by UKPDS Brain Bank Criteria. Neurological examination was conducted for MMSE scores and H and Y staging. Findings were recorded in predesigned and pretested questionnaire.

RESULTS
Out of 50 participants, 32% (16) belong to the age group of 61-70 years, and 56% were males. 60% were newly diagnosed during the study period. 50% had duration of illness of <1 year followed by 1-3 years (32%). Decreased libido was most common symptom (70%). Unsatisfactory voiding of the bowel was the most common in gastro intestinal symptom accounting for 70%. Dementia, anhedonia, and attention deficits were (62%) common neuropsychiatric symptoms. Insomnia was most prevalent symptom (82%).

CONCLUSION
The non-motor symptoms were universally prevalent in all the patients with Parkinson’s disease. The number of non-motor symptoms increased as the stage of the Parkinson’s disease progressed. Early recognition and treatment of non-motor symptoms is required to improve the quality of life.

KEYWORDS
Parkinsonism Disease, Non-Motor Symptoms.