JOURNAL OF EVIDENCE BASED MEDICINE AND HEALTHCARE

Table of Contents

2019 Month : July Volume : 6 Issue : 27 Page : 1849-1853

CORRELATION OF SERUM CHLORIDE LEVELS WITH 30 DAY MORTALITY IN HEART FAILURE PATIENTS

Kader Muneer1, Himanshu Gupta2, Ayushi Gupta3

Corresponding Author:
Dr. Himanshu Gupta,
Flat No. 1B, Sreerosh Apartments,
Golf Link Road, Chevayur,
Kozhikode- 673017, Kerala.
E-mail: dr.himguru@yahoo.com
DOI: 10.18410/jebmh/2019/377

ABSTRACT
BACKGROUND
Heart failure is commonly associated with electrolyte imbalances. Hyponatraemia has established prognostic role in heart failure, but association of hypochloraemia is still lacking. We wanted to study the impact of admission serum chloride levels in relation to serum sodium levels in 30-day outcomes after hospitalization for acute decompensated heart failure (ADHF).

METHODS
Total of 405 consecutive patients with diagnosis of ADHF were assessed for serum sodium and serum chloride levels on admission within the period of 2.5 years, and divided into 3 tertiles based on serum chloride levels and observed for 30 day outcome. Continuous variables were compared using independent t-test while ????2 test was used for categorical variables. p-value ≤ 0.05 considered significant.

RESULTS
Mean age was found to be 62.5 yrs. Overall mortality at 30 days was 24.4% (99) and all deaths occurred in tertile 1 (serum Cl <99), suggesting strong role of hypochloraemia in mortality. Patients in tertiles 2 (99-103) and tertiles 3 (>103) exhibited 100% survival.

CONCLUSIONS
Mortality at 30 days in patients with ADHF is 24.4 percent and serum chloride is strongly and independently associated with poor survival in these patients and has a major contribution in the risk caused due to hyponatraemia.

KEYWORDS
Acute Decompensated Heart Failure, Hypochloraemia, Hyponatraemia.