JOURNAL OF EVIDENCE BASED MEDICINE AND HEALTHCARE

Table of Contents

2019 Month : September Volume : 6 Issue : 38 Page : 2594-2597

COMPARATIVE STUDY OF INTRAVENOUS TRANEXAMIC ACID AND OXYTOCIN VERSUS OXYTOCIN ALONE IN REDUCING BLOOD LOSS DURING AND AFTER LSCS UNDER SPINAL ANAESTHESIA

Utpal Kumar Ray1, Aftabuddin Mondal2

Corresponding Author:
Dr. Aftabuddin Mondal,
#24, Gorachand Road,
Kolkata-700014, West Bengal.
E-mail: aftabuddinmondal5@gmail.com
DOI: 10.18410/jebmh/2019/534

ABSTRACT
BACKGROUND
Cesarean section (CS) rates have been increased to as high as 25 to 30% in many areas of the world. Risk of postpartum haemorrhage increases in cases of cesarean section & PPH is a major cause of maternal morbidity & mortality. Routinely uterotonics are used for active management of third stage of labour. Tranexamic acid by its antifibrinolytic action further reduces blood loss. This study will evaluate the efficacy and safety of tranexamic acid in combination with uterotonic drugs in reducing the blood loss after placental delivery following lower segment caesarean section (LSCS).

METHODS
A randomized, case controlled, prospective study was conducted on 100 women undergoing lower segment cesarean section (LSCS) at term between 37 and 41 wks. and have been studied prospectively. They are divided in two groups, 50 control &50 cases. Cases (50) were given tranexamic acid immediately before LSCS along with 10 units of oxytocin whereas control group were given 10 units of oxytocin alone after delivery of foetus. Blood loss was collected and measured during two periods.

RESULTS
The patient characteristics, namely age, height, weight, gestational age and gravidity in two groups were similar which was statistically insignificant. There was no episode of thrombosis in the study. Tranexamic acid significantly reduced the quantity of the blood loss from time of placental delivery to 2 hours postpartum (p<0.001) and from end of LSCS to 2 hours postpartum (p<0.001). However there was no statistical difference in quantity of blood loss from time of placental delivery to end of LSCS in both groups.

CONCLUSIONS
A safe dose of Tranexamic acid has an effective role in reducing blood loss during LSCS without causing adverse reaction. Thus the drug can be used effectively in reducing maternal morbidity and mortality during LSCS.

KEYWORDS
Cesarean section, Tranexamic acid, Blood loss