JOURNAL OF EVIDENCE BASED MEDICINE AND HEALTHCARE

Table of Contents

2019 Month : November Volume : 6 Issue : 46 Page : 2940-2944

Comparison of HbA1c and Lipid Profile with Severity of Coronary Artery Disease in Diabetic Patients Presenting with Acute Syndrome

Basavaraj Baligar1, Mamatarani R. H.2, N. S. Hiregoudar3, Ishwar S. Hasabi4

ABSTRACT
BACKGROUND
DM is characterized by insulin resistance and dyslipidaemia, in particular, high levels of total cholesterol, triglycerides and LDL, and low levels of HDL-C, which confers increased risk for CAD that may manifest as life threatening ACS. We wanted to study the correlation between HbA1c & total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL) in diabetic patients presenting with acute coronary syndrome and also their correlation with severity of ACS independently.

METHODS
Blood samples of 50 known diabetic patients presented to emergency with ACS were sent for HbA1c & lipid profile estimation. All patients underwent coronary angiography. Obtained results were statistically analysed & correlated.

RESULTS
Statistically significant direct co-relationship was found between HbA1c, LDL, Total cholesterol, ACS severity (SVD/MVD) & inverse co-relationship with HDL.

CONCLUSIONS
In our study we concluded that there is strong correlation between HbA1c and dyslipidaemia, with severity of coronary artery disease. HbA1c, total cholesterol, LDL cholesterol are directly proportional and HDL cholesterol is inversely proportional to the severity of coronary artery disease. Hence incidence of ACS can be minimized with adequate glycaemic control.

KEYWORDS
Diabetes, HbA1c, Lipid Profile, Coronary Artery Disease