JOURNAL OF EVIDENCE BASED MEDICINE AND HEALTHCARE

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2020 Month : June Volume : 7 Issue : 27 Page : 1265-1269

A Study on Evaluation of Thyroid Function in Pregnancy with Pregnancy Outcome in a Tertiary Care Centre.

Divya Sara Raju1, Jisha Ismail2, Anjali Prem3

Corresponding Author:
Dr. Jisha Ismail,
Assistant Professor,
Department of Obstetrics and Gynaecology,
Government Medical College,
Thrissur, Kerala, India.
E-mail: jishajameel@gmail.com

ABSTRACT

Thyroid disease is the second most common cause of endocrine dysfunction in women of childbearing age. Fetus is dependent on maternal thyroxine and drugs that affect the maternal thyroid also affect the fetal gland.

METHODS
Study Design
Prospective study. Setting: Department of Obstetrics and Gynaecology, Institute of Maternal and Child Health, Medical College, Calicut. Study population: Pregnant women with abnormal TFT detected in the first trimester or early second trimester were included. Age, parity, type of thyroid dysfunction, symptoms and signs were recorded. Incidence of hyperemesis, previous abortions and prolonged period of infertility were also recorded. Incidence of various maternal & fetal complication were studied.

RESULTS
Out of 131 cases, 77 were hypothyroid and 54 were hyperthyroid. Overt hypothyroid 51 (38.9%), subclinical hypothyroid 26 (19.8%), overt hyperthyroid 39 (29.8%) and subclinical hyperthyroid 15 (11.5%). 40.5% of thyroid disorders complicating pregnancy occurred in the age group of 20-25 years. PIH (27.5%) anaemia (50%) IUGR (38.5%) Oligamnnios (26%) were observed during antenatal period. preterm labour (19.8%), LBW babies (38.2%) are also observed among these women. 20.6% babies needed NICU admission.

CONCLUSIONS
Thyroid dysfunction during pregnancy is quite common in our population, hypothyroidism is more common than hyperthyroidism. Thyroid dysfunction during pregnancy especially hyperthyroidism is associated with hyperemesis & has to be detected by routine screening. Thyroid dysfunction may have adverse effect on fertility & cause RPL. Maternal complication like PIH, Anaemia, Oligamnnios, preterm labour & foetal complication like IUGR, LBW, NICU admission are also common in thyroid disorders complicating pregnancy.

KEYWORDS
Overt Hypothyroidism, Overt Hyper Thyroidism, Subclinical Hypothyroidism, Subclinical Hyper Thyroidism