JOURNAL OF EVIDENCE BASED MEDICINE AND HEALTHCARE

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2020 Month : July Volume : 7 Issue : 31 Page : 1526-1530.

Analysis of Malignancies in HIV Positive Patients: Observational Study in a Tertiary Care Hospital of Jharkhand.

Alok Ranjan1, Nisha Khanna2, Ashwin Kumar3

BACKGROUND

There is scarcity of data on the frequency of malignancies in HIV infected individuals from Jharkhand. We wanted to analyse the pattern of malignancies in patients with HIV-AIDS based on their age and sex and document the CD4 counts at the time of diagnosis of the malignancy.

 

METHODS

We conducted a retrospective analysis of data of all patients presenting with a malignancy and coexisting HIV-AIDS from January 2017 through December 2019 were analysed initially. The pathological diagnosis, clinical stage, and the CD4 cell count at diagnosis, were noted.

 

RESULTS

There was a total of 150 patients. Of that total, 80 (53%) were men, and 70 (47%) were women. The mean age was 45 years (range 20 - 65 years). The three most common malignancies observed were Non-Hodgkin’s lymphoma (24%), squamous cell carcinoma (SCC) of cervix (22%) and squamous cell carcinoma of head and neck (19%). At lower CD4 counts (<250 cells/μL), NHL was the most frequent malignancy. At well preserved CD4 (>250 cells/ μL), HNSCC and SCC of cervix were more frequently observed.

 

CONCLUSIONS

In present study, AIDS defining malignancies were more common than non-AIDS defining malignancies. A comprehensive approach towards the treatment of these patients giving adequate therapy for both the conditions, is the need of the hour.

 

KEYWORDS

AIDS Defining Malignancies, HAART, HIV, Non-AIDS Defining Malignancy, Non-Hodgkin’s Lymphoma