A. Jeevan Babu, Yedoti Vijayakumari, Kodekonda Sudheer
BACKGROUND Post-operative nausea and vomiting are the common complaints in patients undergoing surgery under general anaesthesia. This is one of the factors that determine the length of hospital stay after anaesthesia. The concept of day care surgery requires good, enhanced, quick post-operative recovery, for early discharge from the hospital. This requires a better antiemetic without any adverse effects. We wanted to compare efficacy of Ondansetron, Granisetron, and Palonosetron in patients undergoing abdominal surgeries, under general anaesthesia, in prevention of post-operative nausea and vomiting. METHODS A prospective randomized control study was carried out, from June, 2016 to December, 2018 in the Department of Anaesthesia, Sri Venkateswara Medical College. Patients undergoing abdominal surgeries, under general anaesthesia were included in the study after fulfilling the inclusion and exclusion criteria. They were divided into 3 groups and antiemetics were given. Presence nausea, vomiting, requirement of rescue antiemetic and adverse effects of drugs were measured. RESULTS Incidence of postoperative nausea and vomiting were noted for 24 hours postoperatively. We could not find any major adverse drug reactions in the study. CONCLUSIONS Palonosetron was found to be effective in preventing post-operative nausea and vomiting, without any adverse reaction in the study in comparison with other drugs.
