Disha Ubeja1 , Ravishankar R.B.2
BACKGROUND Intravenous anaesthesia is an integral part of modern anaesthesia. But till date there is no single intravenous agent which fulfils all the characteristics of an ideal anaesthetic agent. The technique of co-induction is to administer a subanaesthetic dose of another inducing or sedative agent, so as to reduce the dose of primary agent. Propofol in the most frequently used IV anaesthetic agent used today, providing faster onset of action, antiemesis, rapid recovery with attenuation of pharyngeal, laryngeal and tracheal reflexes. The major disadvantages of propofol induction are impaired cardiovascular and respiratory function, which may put the patient at a higher risk of bradycardia, hypotension and apnoea. METHODS 150 patients of either sex in the age group of 18 to 65 years, undergoing elective surgeries were randomly selected and informed consents were taken. The study population was divided into three groups with 50 patients in each group. Group KP- 0.4 mg/Kg ketamine; Group MP- 0.03 mg/Kg midazolam and Group C- 10 mL NS. RESULTS Requirement of induction dose was reduced in both the groups and the induction dose was the least in group KP. Changes in haemodynamic parameters ere greater in group c and group MP as compared to group KP. CONCLUSIONS Co-induction with ketamine provides better hemodynamic stability and lesser induction dose of propofol as compared to midazolam. Therefore, ketamine is preferred as a co-induction agent to propofol.
