A Prospective Study on Analysis of Histopathological Variations in Post Cholecystectomy Specimens Done for Benign Conditions in a Tertiary Care Hospital, Tirupati

Abstract

Gandikota Venkata Prakash1, K. Ajay Babu2, Madan Sundar3, G. Purushotham4, Saddi Tejaswi5, Vuribindi Manognitha Reddy6

BACKGROUND
Cholecystectomy is a common surgical procedure done worldwide for both benign
and neoplastic conditions. Cholecystectomy for benign conditions is performed
based on clinical signs, symptoms, Ultrasound, CT. Hence there is fair chance of
missing early malignant lesions like carcinoma-in-situ and other early carcinomas.
Aim: The aim of the study is to analyse histopathological variations in post
cholecystectomy specimens done for benign lesions.
METHODS
The study was conducted in Department of General Surgery, SVRRGGH, Tirupati,
for a period of one year, from March 2019 to April 2020. This is a prospective
Study conducted among 100 Patients, conducted over a period of one year from
time of IEC approval from March 2019 to April 2020. All patients who underwent
cholecystectomy for benign biliary disease and gall stone were included in the
study. All patients with pre-diagnosed empyema gallbladder, gallbladder
malignancy, gallbladder mass, and gallstones associated with obstructive jaundice
are excluded from the study.
RESULTS
In our study, 100 cases of gall bladder disease were studied in the age group of
18 – 70 years, for a period of 1 year from March 2019 in the department of General
surgery, SVRRGGH. Occurrence is high in patients of age group 18 – 45 years (65
%). The male to female ratio is 0.5:1 with female preponderance. The most
common histopathologic finding was chronic calculus cholecystitis (59
%).Adenocarcinoma of gall bladder (2 %) of the cases with no preoperative
suspicion of malignancy.
CONCLUSIONS
The occurrence of Incidental GBC found in my study is 2 %. Due to high estimate
of residual disease, re-resection is still a curative option and is to be considered
for pT2 & pT3, but not CBD removal. Prognosis usually is dismal, and five-year
survival rates have been reported to be less than 5 % for more advanced stages.
 

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