Santosh Kumar Swain1, Aswini Kumar Rout2, Sriprasad Mohanty3, Prabhat Kumar Padhi4, Roma Rattan5, Ashok Kumar Behera6
BACKGROUND
Diabetes mellitus (DM) is a metabolic disorder, characterized by hyperglycaemia,
insulin deficiency and insulin resistance. Along with diet, exercise, and oral
antidiabetic drugs (OADs), probiotic intervention in novel food formulations
enriched with specific bacterial strains could also be effective. In patients with type
2 DM and obesity, there is alteration in composition of the gut microbiota resulting
in moderation of intestinal permeability and increasing endotoxin secretion. The
utility of probiotic therapy in the management of type 2 DM has not been fully
explored. Probiotics also regulate gut microflora and plasma lipids. The study was
designed with a purpose of assessing the role of probiotics in glucose and lipid
metabolism and its effectiveness in controlling blood sugar and lipid profile in type
2 DM.
METHODS
The single-blind randomized controlled study was conducted from February 2019
to January 2020 in the Department of Medicine, SCB Medical College and Hospital,
Cuttack, in patients of type 2 DM. A total of 80 patients were included in the study
with 40 as cases and another 40 as controls. Statistical analysis was performed
using SPSS version 20. The mean ± standard deviation, median and ranges were
calculated using chi square test and independent t-test. The level of significance
was considered as P < 0.05.
RESULTS
The FBS and HbA1C levels were decreased by 16 mg / dl and 0.5 % respectively
after consuming probiotics (P < 0.001). The total cholesterol, triglyceride, low
density lipoprotein was decreased and high density lipoprotein level was increased
after taking probiotics which was significant (P < 0.001). Probiotics help in
cholesterol reduction through different mechanisms.
CONCLUSIONS
Probiotics have a definite role in improving glycaemic status and lipid levels in type
2 DM.
