Ashok V1, Divya R2, Karthikeyan K3
INTRODUCTION
Psoriasis is the dermatological disorder characterized by hyperproliferation and inflammation of the skin. The free radicals produced by oxidative stress leads to oxidation of polyunsaturated fatty acids resulting in the formation of lipid peroxidation products such as malondialdehyde (MDA) which is a biomarker of oxidative stress.
MATERIALS AND METHODS
This was a hospital based case control study which included 50 cases of psoriasis and 50 healthy controls. Serum malondialdehyde was measured by thiobarbituric acid reactivity assay method. For the patients with psoriasis, clinical severity was determined according to Psoriasis Area Severity Index (PASI) score. Data analysis was done using SPSS software version 16.0.
RESULTS AND DISCUSSION
Our results showed levels of MDA were significantly increased (P<0.001) in patients with psoriasis as compared to controls. We found a positive correlation between the serum MDA and PASI score. These results supported the proposal that serum MDA level could be helpful in predicting the prognosis of psoriasis and add further support for the involvement of oxidative stress in the pathogenesis of psoriasis.
CONCLUSION
Our results indicate that oxidative damage resulting from increased reactive oxygen species production may be involved in the pathogenesis of psoriasis.
