Rajkumar Gurulingayya Hiremath, Durgaprasad Mallappa Kabade, Prashant Kumar Malkiwodeyar, Ameet Vasanthrao Khatawkar, Jagdeesh Gangadhar Mahajanshettar, Ganeshgouda Majigoudra,Veeresh Basavaraj Hubballi
BACKGROUND In cases of Acute Decompensated Heart Failure (ADHF) Loop diuretics are an important component of current treatment and are administered to approximately 90% of patients who are hospitalized with heart failure1. Despite decades of clinical experience with these agents, there are few studies to guide their use. MATERIALS AND METHODS Total 60 patients included in the study (30 in each group), were randomized into two groups – High dose and Low dose furosemide therapy group. Following were considered as the end points, negative fluid balance at 24 hours after admission, duration of hospital stay, trend of serum electrolytes, clinical outcome (death and hospital re-admission). RESULTS We noticed that there was significant diuresis in the first 24 hours and shorter hospital stay in high dose diuretic group. There was no significant difference in serum sodium and potassium levels and hospital re-admission. There was significant difference in the renal parameters with transient elevation in serum urea and creatinine, seen in high dose group as compared to low dose group. CONCLUSION Both high dose and low dose diuretic modality of treatment have equal role in the management of ADHF. High dose diuretic strategy has been associated with shorter hospital stay and rapid improvement in clinical symptoms so, it might be effective diuretic strategy.
