Rajesh LG* and Balakrishna H Namdhari
BACKGROUND AND AIMS
In the past decade origin of high grade serous carcinoma of ovaries has its origin from the clonal expansion of the secretory cells of the distal fallopian tube. We have tried to see the relationship based on morphological and immunohistochemically studies of the lesion known as “Serous Tubal Intraepithelial Carcinoma” (STIC), which resembled high grade serous carcinoma of ovary. To study the association between ovarian surface epithelial serous tumours and STIC.
MATERIALS AND METHODS
We studied 143 consecutive cases of ovarian surface epithelial serous tumours retrospective and prospective study from July 2009 to June 2019, which includes 99 cases of benign serous cyst adenomas, 8 were borderline and 36 were high grade serous carcinomas of ovary. Complete examination of the fallopian tubes from each case was done according to serial Sectioning and Extensive Examination of Fimbria (SEE-FIM) protocol from July 2009. Immuno-staining for p53 was done on sections from ovary and fallopian tube.
RESULTS
STIC lesions was identified in fallopian tubes from 9 cases of high grade serous group (25 %) while no STIC was identified in non-high grade serous group. Fimbrial end of fallopian tube were involved in all the cases. Results are compared using chi square test. A statistically significant association was found between high grade serous carcinoma group and STIC (p=0.003)
CONCLUSION
STIC coexists with a significant number of high-grade serous carcinoma of ovary cases and further studies are needed to detect STIC in early stages of high grade serous carcinoma of ovary.
