Wadgaonkar Udit Rajendra1 , Neelakandan Ramya2 , Sethu Prabhu Shankar3
BACKGROUND Chronic Kidney Disease (CKD) is growing in complexity in both developing and developed countries. Neutrophil to lymphocyte ratio (NLR) plays a vital role in CKD. NLR can be taken as a predictor of future complications. We wanted to measure and study the correlation of NLR with renal parameters in chronic kidney disease. METHODS This is a control study conducted over a period of 2 months in Aarupadai Veedu Medical College Hospital, Pondicherry. During this period all consecutive subjects diagnosed with CKD were taken as cases and apparently healthy thirty adults were included as controls. Demographic data, neutrophil count, lymphocyte count, urea, creatinine, and uric acid in controls and cases were collected. The collected data was coded, entered into Microsoft Excel work sheet and exported to SPSS 21. Independent t test was used for test of significance and also correlation was calculated. NLR between controls and cases was also correlated. RESULTS The mean age of the study subjects was 60.7. Out of the 64 cases 46 subjects were males and 18 subjects were females; there were 14 male controls and 16 female controls. The ratio of cases to controls was close to 1:2. The mean blood urea level was 88.3 ± 52.6 for cases and 22.1 ± 5.85 for controls. The mean serum creatinine level for cases was 4.7 ± 3.1 and 0.98 ± 0.18 for controls. The mean serum uric acid level was 7.3 ± 0.5 and 3.9 ± 0.5 for cases and controls respectively. The mean difference between these two groups was significant (p<0.001). The correlation value between blood urea, serum creatinine & NLR among cases showed a very weak positive correlation. CONCLUSIONS Neutrophil Lymphocyte Ratio is simple, reliable indicator of worsening of renal function in CKD.
