Chandrashekar, Avinash Patil, Ishwar S. Hasabi, Chetan K. Ganteppanavar, Basavaraj D. Baligar
BACKGROUND India is popularly known as diabetic capital of the world. Every day, hundreds of new diabetics are added to the existent pool of the diabetics. The bulk and prevalence of diabetics is increasing every day at an alarming rate. Unlike many other organs affected like eyes, kidneys and nerves, liver is also one of the major organ affected. The spectrum of disorder ranges from simple abnormal liver enzyme status to frank cirrhosis. Liver has also major role in maintaining body sugar homeostasis as it is the site of glycogenolysis and gluconeogenesis. In this study, we would like to know more about the spectrum of abnormalities associated with hepatic metabolism as very few studies have been done previously. MATERIALS AND METHODS The study is a prospective and cross-sectional study done with 350 cases attending the KIMS, Hubballi Hospital. The population is aged more than 40 years and are diagnosed case of type 2 diabetes. Ultrasonography, liver function tests and many other relevant investigations are done. Alcoholics and patients with hepatocellular carcinoma, etc. are excluded from study. RESULTS 350 cases were included in the study and 46% of cases (161) had fatty liver. Among them, 54.6% were males and 45.3% were females. It was also noticed that HbA1c was >9 gm% in patients with fatty liver. Obesity is a frequent association with fatty liver. ALT and AST, both were elevated and ALT being more elevated than AST. Triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol was also higher when compared with non-alcoholic fatty liver group. CONCLUSION Non-alcoholic fatty liver disease is higher in patient with type 2 diabetes mellitus. Insulin resistance is also having a positive correlation with NAFLD. Better glycaemic control results in prevention of early disease progression and complications.
