Simbita A. Marwah1 , Mihir D. Mehta2 , Ankita K. Pandya3 , Amit P. Trivedi4
BACKGROUND The prevalence of diabetes mellitus ranges from 0.4 - 3.9% in rural areas to 9.3 - 16.6% in urban areas, in India. Diabetes causes long term dysfunction of various organs like heart, kidneys, eyes, nerves, and blood vessels. Hyperuricemia is defined as serum uric acid concentration in excess of urate solubility. In nondiabetic subjects, an elevated level of uric acid has been shown to be an independent predictor of coronary heart disease and total mortality. Also elevated levels of uric acid is a risk factor for peripheral arterial disease. METHODS This is a cross sectional study conducted over a period of 1 year. 565 individuals visiting the routine health check-up were included in the study. Serum uric acid, glycated haemoglobin (HbA1c) and glucose were estimated on Siemens Dimension auto analyser. Descriptive statistics was applied for frequency and Mean ± SD were derived for all the parameters. One-way Anova, unpaired two sample ‘t’ test was applied for gender - specific and age - specific group comparisons for all the markers. Correlation analysis was performed using the Pearson’s correlation method. p values <0.05 were considered statistically significant. RESULTS This study comprised of 565 individuals, of which there were 267 cases and 298 controls. Levels of HbA1c were significantly increased in patients with diabetes mellitus (8.3 ± 1.5 mg/dL) as compared to control group. (5.9 ± 0.3 mg/dL; p <0.001). Furthermore, Uric acid levels were also significantly increased in patients with diabetes mellitus (8.1 ± 1.2 mg/dL) as compared to control group. (4.6 ± 1.0 mg/dL; p <0.001). There was a significant correlation between uric acid and HbA1c levels (r = 0.132, p =0.031) and also between uric acid and FBS level (r = 0.155, p = 0.011) in patients with diabetes mellitus. CONCLUSIONS Our data suggested a positive correlation between altered blood glucose and serum uric acid levels and between serum uric acid and HbA1c levels. From our study we deciphered that high serum uric acid levels were associated with diabetes mellitus. Thus, serum uric acid may serve as a potential biomarker of the deterioration of glucose metabolism.BACKGROUND The prevalence of diabetes mellitus ranges from 0.4 - 3.9% in rural areas to 9.3 - 16.6% in urban areas, in India. Diabetes causes long term dysfunction of various organs like heart, kidneys, eyes, nerves, and blood vessels. Hyperuricemia is defined as serum uric acid concentration in excess of urate solubility. In nondiabetic subjects, an elevated level of uric acid has been shown to be an independent predictor of coronary heart disease and total mortality. Also elevated levels of uric acid is a risk factor for peripheral arterial disease. METHODS This is a cross sectional study conducted over a period of 1 year. 565 individuals visiting the routine health check-up were included in the study. Serum uric acid, glycated haemoglobin (HbA1c) and glucose were estimated on Siemens Dimension auto analyser. Descriptive statistics was applied for frequency and Mean ± SD were derived for all the parameters. One-way Anova, unpaired two sample ‘t’ test was applied for gender - specific and age - specific group comparisons for all the markers. Correlation analysis was performed using the Pearson’s correlation method. p values <0.05 were considered statistically significant. RESULTS This study comprised of 565 individuals, of which there were 267 cases and 298 controls. Levels of HbA1c were significantly increased in patients with diabetes mellitus (8.3 ± 1.5 mg/dL) as compared to control group. (5.9 ± 0.3 mg/dL; p <0.001). Furthermore, Uric acid levels were also significantly increased in patients with diabetes mellitus (8.1 ± 1.2 mg/dL) as compared to control group. (4.6 ± 1.0 mg/dL; p <0.001). There was a significant correlation between uric acid and HbA1c levels (r = 0.132, p =0.031) and also between uric acid and FBS level (r = 0.155, p = 0.011) in patients with diabetes mellitus. CONCLUSIONS Our data suggested a positive correlation between altered blood glucose and serum uric acid levels and between serum uric acid and HbA1c levels. From our study we deciphered that high serum uric acid levels were associated with diabetes mellitus. Thus, serum uric acid may serve as a potential biomarker of the deterioration of glucose metabolism.
