Swayam Prava Pradhan 1 , Anusuya Dash 2 , Sulata Choudhury 3 Debi Prasad Mishra
BACKGROUND Infertility is a common problem in day-to-day practice. Therefore, the common uterine pathology should be excluded while investigating infertility. Endometrial biopsy plays an important role in diagnosing infertility and assessing the glycogen content of endometrium, which is essential for implantation of fertilised ovum. The aim of the study is to find out endometrial pathologies and glycogen content of endometrium as causes of infertility. MATERIALS AND METHODS A study of 139 cases of primary and secondary infertility was carried out in the Department of Pathology, M.K.C.G. Medical College, Berhampur. Women with history of infertility were subjected to premenstrual endometrial biopsy. Routine haematoxylin and eosin staining was done for dating endometrium. Endometrial specimens were evaluated in the light of menstrual history to find out various endometrial changes in them. Periodic Acid-Schiff stain was done to detect amount of glycogen in the endometrium. RESULTS Primary infertility was detected in 85.6% of cases (n=119) and secondary infertility in 14.4% (n=20) of cases. Maximum incidence of infertility was seen among patients between 23 and 27 years of age. Anovulatory cycles were seen in 29.5% (n=41) of cases. Glycogen deficiency was seen in 28.88% (n=26) of cases. Tubercular endometritis was found in 3.9% (n=4) of cases and cystic glandular hyperplasia seen in 2.5% (n=3) of cases of primary infertility. CONCLUSION Endometrial pathologies are important causes of infertility and depletion of glycogen results in inadequate preparation of endometrium, which maybe one of the causes of infertility.
