Santosh Mittal1 , Devindra Kumar Vohra2 , Parul Mittal3
BACKGROUND The emergence of drug resistance and development of multidrug resistance tuberculosis (MDR TB) has become a new but significant obstacle for TB control. As rifampicin resistance is an important indicator for drug resistant tuberculosis, rapid diagnosis of tuberculosis and detection of rifampicin resistance are essential for knowing the magnitude of the problem and early management of drug resistant tuberculosis (DR TB). The aim of this study is to determine the magnitude of rifampicin resistance in the sputum positive presumptive drug resistant tuberculosis, by using CBNAAT and thus to focus on magnitude of the problem of drug resistant tuberculosis. METHODS This is a cross sectional observational study carried out over a period of 8 months in a tertiary care hospital in western U.P. In this study, 182 sputum positive cases of pulmonary tuberculosis, who were potential presumptive drug resistant tuberculosis, were included. Their sputum samples were collected and tested by CBNAAT (an automated cartridge based nucleic acid amplification test) to detect presence of mycobacterium tuberculosis and also status of rifampicin resistance. The results were analysed. RESULTS Out of 182 patients, mycobacterium tuberculosis was detected in all 182 patients and out of these 182 patients, rifampicin resistance was found in 16 cases (8.79%). Male and female ratio was 3:1 among rifampicin resistant cases. Regarding age distribution, maximum no. of patients with rifampicin resistance were in the age group of 40-50 yrs. (50%), followed by 20-30 yrs. (25%). CONCLUSIONS Rifampicin resistant cases are found in moderate number of presumptive drug resistant tuberculosis. They were mostly male, and 40-50 yrs. of age.
