Sowmya D.1, Anusha S.2, P. Hari Babu Pidaparti3, Jaya Chandra T.4, K. Mytri Priyadarshini5
BACKGROUND
Prostate is an associated gland of the male reproductive system. Worldwide,
among the men, prostate cancer (PC) is the second most common cancer. PC is
the seventh commonest cancers among the Indian male. Studies reported that
diffusion weighted imaging (DWI) and dynamic contrast enhanced imaging
(DCE-MRI), can offer additional value in localizing cancer. A study was conducted
to evaluate and correlate the role of DWI in detection and staging of PC and
correlation with histopathology.
METHODS
A cross-sectional observational study was conducted in the Department of
Radiodiagnosis, GSL Medical College, over a period of 18 months. Males with
symptoms of nocturia, urinary urgency, frequency, hesitancy and bone pain were
included in the study. Trans rectal ultrasound scan (TRUS) biopsy was collected,
Gleason‘s score (GS) was considered for the histopathologic analysis. The
evaluation of DWI as a tool for detection of PC was based on comparing the
sensitivity and specificity of the results after taking histopathology as the gold
standard test chi-square test was used to find the statistical significance and P <
0.05 was considered statistically significant.
RESULTS
Total, 36 (82 %) were diagnosed to be malignant, maximum number (18; 50 %)
were between 61 – 70 years age group. Peripheral zone is the most common
(61.2 %; 22) area for the PC followed by transitional (33.3 %) and central zone
(5.5 %). In this study, 16.6 % members had GS ≤6; Apparent diffusion
coefficient (ADC) was ranged between 0.81 to 0.87 and mean + SD were 0.85 +
0.02. Out of the 22.2 % members whose GS was 7, the mean + SD ADC were
0.74 ± 0.02. For 22 (61 %) members, GS was >8; the mean + SD ADC was 0.63
± 0.08; statistically there was significant difference between the parameters.
Magnetic resonance imaging (MRI) revealed that 61.3 % (27) cases as highly
suspicious, 25 % (11) as probably malignant and 13.6 % (6) as indeterminate;
the sensitivity for MRI was 94.5 % and specificity was 85.7 %.
CONCLUSIONS
Patients with increased prostate specific antigen (PSA), multi-parametric
magnetic resonance imaging (MPMRI) is valuable, non-invasive and a better
option to detect PC. Also helps in localizing the exact location.
