Chitra Kuriakose, Sebastain Abraham, Manjula V. D, V. S. Sumadevi, Annamma Kurien
BACKGROUND: Glomerular Filtration Rate (GFR) is the best index for assessing kidney function. Ethnicity has a potential influence on GFR. Anatomic and physiological changes of ageing kidney influences GFR. AIMS AND OBJECTIVES: To find age related variations of GFR in a population of Kerala. SUBJECTS AND METHODS: A total of 519 subjects of all ages from the community were screened. Blood pressure, diabetes, mellitus, proteinuria, serum creatinine being checked. Estimated GFR (e GFR) assessed using modification of diet in renal disease [MDRD formula]. RESULTS: The mean e GFR of the population was found to be 61.2±18.2ml/min. and the e GFR of normal subjects excluding diabetes, mellitus, blood pressure and proteinuria was found to be 64.49±20.5ml/min. e-GFR was more for males compared to females, 67.5± 20ml/min and 55.4±14ml/min respectively. e GFR showed a steady decline as the age advanced and it was statistically significant(p < 0.05). CONCLUSION: The age adjusted e GFR of keralite population is much less compared to western standards. A more detailed study in general population is needed.
