Lubna Khan1, Aparna Singh2, Jagjeewan Ram3, Namrata Nigam4
BACKGROUND
Obstetric practitioners routinely deal with antenatal patients who have high risk of
developing established coagulopathy, which leads to a very high incidence of
maternal morbidity and mortality. We wanted to assess the role of blood
components in preventing disseminated intravascular coagulation (DIC) in highrisk
patients and determine the amount of blood components required along with
the rate of improvement in the DIC score, during treatment of high-risk obstetric
patients of DIC and in patients with established DIC.
METHODS
This is an interventional study. 274 obstetric patients who were at high risk for
developing DIC and / or with established DIC admitted during the 20 months study
duration were included in the study. Patients were categorized in to three groups
based on the DIC score according to ISTH scoring system in to non-overt and
overt DIC groups. Those with DIC score < 5 were grouped as IA and IB randomly
and those with DIC score > / = 5 were grouped as II. Software used was ANOVA
using variance ratio F test for testing the significance between groups and chisquare
test was used to find out the association between the groups or parameter.
RESULTS
Prophylactic transfusion of blood components showed faster rate of improvement
than control group. Average consumption of blood components was more in
patients of established coagulopathy as compared to non-overt group.
CONCLUSIONS
Transfusion of blood components can prevent overt DIC in high-risk patients.
