Lata Manchala 1 , Devender Reddy Kotta 2 , Shrinivas Bheemrao Somalwar 3 , Ezhil Arasi Nagamuthu 4
BACKGROUND GIST is a subset of mesenchymal tumours arising from interstitial cells of Cajal. GIST has become very important since the availability of specific pathogenesis targeted treatment with the KIT/PDGFRA tyrosine kinase inhibitor, imatinib mesylate. MATERIALS AND METHODS It is a prospective and retrospective study. The study was conducted at the Upgraded Department of Pathology, Osmania General Hospital, Hyderabad, from 2013-2015 on 40 tumour samples. Immunohistochemistry using CD117, DOG1 and Ki67 was done on all cases along with routine histopathological assessment on H and E stained slides. RESULTS The immunopositivity of various markers is observed in different grades depending upon the tumour grade and locations. CONCLUSION CD117, DOG1 and Ki67 are important key diagnostic and prognostic biomarkers in the assessment of GIST across all the mesenchymal tumours of GIT
