Debahuti Mohapatra1 , Rajashree Tripathy2 , Prateek Das3 , Pallak Batalia4
BACKGROUND Malignant lymphoma (ML) is one of the most common cancers, accounting for 3.37 % of all malignancies and is more prevalent in developed countries. Distribution of different subtypes of ML varies in different geographical locations according to the World Health Organization (WHO) classification. METHODS This is a retrospective study conducted over a period of one and a half years (July 2017 - December 2018) among hundred and six cases of ML, which were archived from the database of a tertiary care teaching hospital, Bhubaneswar. Clinical history, radiological findings, biochemical and haematological profile were taken into account. Haematoxylin and eosin stained slides and immunohistochemical (IHC) slides were studied by three pathologists including the first author. The diagnosis was reviewed after doing a battery of immunohistochemical lymphoma markers and categorized as per World Health Organization (WHO) 2016 classification. One year follow up was done after administration of chemotherapy. RESULTS Incidence of Hodgkin Lymphoma (HL) is much lower than Non-Hodgkin Lymphoma (NHL), with a HL to NHL ratio of 1 : 2.78. Amongst HL, mixed cellularity (MC) was the commonest type (57.14 % of HL) and in NHL, diffuse large B cell lymphoma (DLBCL) was the commonest subtype (53.85 % of NHL). The commonest nodal site involved irrespective of type of B cell NHL was cervical lymph node and that of extranodal site was stomach. T cell NHL showed peripheral T cell lymphoma (PTCL) as predominant subtype (10.26 % of NHL) majority of which showed extranodal involvement. CONCLUSIONS Recent WHO classification (2016) has made significant alterations to the previous (2008) classification. This is based on immunohistochemical profile, molecular and cytogenetic studies. This study attempts to categorise various lymphomas as per WHO (2016) classification which not only has diagnostic implication but also has significant prognostic and predictive value.
