Govind Sharma1, Bharat Khadav2, T. C. Sadasukhi3, Manish Gupta4, H. L. Gupta5
BACKGROUND
The urinary stone disease is one of the most common afflictions of the modern society and it has been described since antiquity with the westernisation of global culture. It has led to a lot of distress physically, mentally and financially to the affected individuals. Mini-invasive techniques like ESWL and ureteroscopy have their own negative aspects with discomfort to the patient being the prime in it. Hence, a need for conservative management in the form of pharmacotherapy has arisen in the past years and here we are investigating the same. The aim of the study is to compare the efficacy of silodosin (8 mg) vs. tamsulosin (0.4 mg) both in terms of the stone expulsion rate and the time to stone expulsion.
MATERIALS AND METHODS
A study comprising of 120 patients between the age group of 18-50 years with sonography-proven unilateral, uncomplicated lower ureteric calculus was undertaken from January 2015 to November 2015. Exclusion criteria were calculus more than or equal to 1 cm. Patients were divided in 2 Groups; Group A received silodosin 8 mg once daily for a month while Group B received tamsulosin 0.4 mg once daily. The patients were followed up weekly or biweekly with imaging studies. The endpoint was the stone expulsion rate and time, the rate of the interventions and the side effects.
Settings and Design- With ethical committee clearance, a prospective study was conducted in the Department of Urology, Mahatma Gandhi Medical College and Hospital, Jaipur, India.
Statistical Analysis- The SPSS16 software was used for the statistical analysis of the data.
RESULTS
Results of our analysis showed that Group A (silodosin) patients were benefited more than Group B (tamsulosin) and it was also backed by the data showing a statistical significance for spontaneous stone expulsion in favour of the silodosin group.
CONCLUSION
Hence, we concluded that silodosin’s efficacy in treating patients with distal ureteric calculus was much better when compared to tamsulosin.
