Niti Kautish, Anita Kant
BACKGROUND
Unsafe abortions are a major cause of maternal morbidity and mortality. Medical abortion, which is preferred over surgical abortion by most women may provide excellent alternative to unsafe abortion and their attendant risks. The primary aim of this research is to compare the efficacy and acceptability of two regimens with different time interval between mifepristone and misoprostol for first trimester MTP.
MATERIALS AND METHODS
The study was carried out in 150 pregnant women opting for MTP during first trimester by medical method. Pelvic ultrasound was done before giving drugs to assess the correct gestational age, intrauterine location of pregnancy and to exclude any obvious pelvic pathology. Women enrolled in the study were randomized to one of the two groups which differ in the time of administration of misoprostol. All 150 women were given Mifepristone 200mg on Day 1. However, 75 women in the study group were given misoprostol 600mcg on Day 2 and remaining 75 women in the control group were given misoprostol 600mcg on Day 3. The effects regarding efficacy, induction abortion interval, side effects and acceptability of two regimens were noted.
RESULTS
1) 98.66% cases in study group and 94.66% in control group had successful abortions (p value>0.05) 2) 94% of cases preferred 24 hours study protocol rather than established protocol of 48 hours for any future MTP (p value < 0.02).
CONCLUSION
The research work helps to derive a conclusion that medical abortion using misoprostol administration 24 hours after mifepristone appears to be equally efficacious and more acceptable than that of the established protocol of 48 hours.
