Susrutha C. Suresh1, Balakrishna S. N2, Nagesh N. S3, Aravinda K. N4, Sathish O5, Vinay B. Nanjegowda6, Venugopal H. Giriyappa7, Savitha Karlwad8
BACKGROUND
Cirrhosis is defined as the histological development of regenerative nodules surrounded by fibrous bands in response to chronic liver injury, which leads to portal hypertension and end-stage liver disease.
The aim of the study is to compare various decompensation patterns in alcohol-related and hepatitis B and hepatitis C virus-related chronic liver disease and to analyse the mortality after decompensation.
MATERIALS AND METHODS
The study was conducted in a tertiary referral hospital between June 2014 - April 2016. It is a prospective observational study of the 385 patients who were diagnosed as suffering from chronic liver disease and managed for various decompensations both on an outpatient and as well on an inpatient basis.
RESULTS
During the study period, a total of 385 patients were diagnosed with chronic liver disease. Among the patients with the diagnosis of CLD, 152 (77.2%) were diagnosed of alcoholic aetiology and 45 (22.8%) of viral aetiology liver disease. The most common forms of decompensation in alcoholic chronic liver disease were found to be ascites (71.7%), jaundice (56.6%) and oesophageal varices (32.2%). The most common forms of decompensations in viral-related chronic liver disease were jaundice (42.2%), ascites (35.6%) and oesophageal varices (28.9%). Patients with viral-related CLD were diagnosed with higher incidence of hepatocellular carcinoma of (24.4%) compared to only 5.3% of patients of alcoholic liver disease. Ascites was found to be the most common form of decompensation associated with mortality (76%). Jaundice (56%), hepatorenal syndrome (44%) and hepatic encephalopathy (24%) were the other common decompensations associated with mortality.
CONCLUSION
In this study, ascites was found to be most common form of decompensation patterns in alcoholic liver disease and jaundice in viral-related CLD. The incidence of hepatocellular carcinoma was found to be higher in viral aetiology CLD. Ascites was found to be the most common form of decompensation associated with mortality.
