Gitimadhuri Dutta, Sunanda Nayak, Kailash Chandra Agrawal
BACKGROUND Metaplastic breast carcinoma is a heterogeneous group of uncommon aggressive type of breast cancer, accounting for 0.2% to 5% of all invasive mammary carcinoma. It is used to denote tumour with mixed epithelial and sarcomatoid components, primary squamous or mixed adenocarcinoma and squamous cell carcinoma. This study was undertaken with an objective to know the incidence of MBC (Metaplastic breast carcinoma) in our population, analyse them with respect to different clinicopathological parameters and to determine different biological behaviour with that of Invasive ductal carcinoma of Breast (Not otherwise specified) IDC-NOS. MATERIALS AND METHODS This study was conducted in the Department of pathology, VIMSAR, Burla from July 2010 to July 2017. 5 cases of MBC and 441 cases of IDC-NOS were retrospectively reviewed. Clinical presentation, pathological findings and type of surgery were evaluated. RESULTS All patients were female with median age of 50 years in case of MBC, whereas in case of IDC-NOS, patients presented in earlier age i.e. from 25 years and eldest one was 85 years old. All the tumours were unilateral with median size of 8 cm (6cm-10cm) in case of MBC. IDC-NOS patients were presented with unilateral mass, but some patients presented with multifocal mass with median size of 4cm (2cm-6cm). All patients had undergone modified radical mastectomy. Out of 5 cases of MBC, 3 patients had metaplastic squamous cell carcinoma, one had heterologous metaplastic carcinoma with chondroid metaplasia another one had matrix producing metaplastic carcinoma. Out of 5 patients, 3 cases showed lymph node metastasis. All the tumours were triple negative. In case of IDC-NOS, 8cases (1.81%) were triple negative. CONCLUSION MBC are large sized tumours as compared to IDC-NOS, usually triple negative with high ki-67 scores indicating aggressiveness and lack of response to usual hormonal therapy. Large series of patients are needed to develop potential therapy for sub groups of the disease.
