Sudhakar B1, Govardhani Yanamadala2, Devika Bangaru3, Varaprasad USSA4
BACKGROUND
Dexmedetomidine, an α2 agonist and fentanyl, an opioid agonist are compared as adjuvant drugs by continuous infusion perioperatively during general anaesthesia to attenuate stress response to anaesthesia and surgical stress.
MATERIALS AND METHODS
Sixty patients were randomly divided into two groups of 30 each. In group F, fentanyl 2 μg/kg loading dose given over 3 mins. before induction followed by 0.5 μ/kg/hr infusion and in group D dexmedetomidine was given intravenously as loading dose of 1 μg/kg over 10 mins. prior to induction followed by continuous infusion at a dose of 0.2-0.8 μg/kg/hr. Haemodynamic variables were recorded continuously.
RESULTS
Dexmedetomidine is effective in controlling stress response perioperatively with haemodynamic stability as compared to the control group (P<0.05) and without any problem in recovery with dexmedetomidine infusion.
CONCLUSION
Dexmedetomidine infusion is effective to control perioperative stress responses during surgery and maintains haemodynamic stability as an adjuvant in general anaesthesia.
