Ruhani Arora1 , Sumitra Kanojiya2 , Vibha Mehta3 , Geetika Duggal4
BACKGROUND Dexmedetomidine a highly selective α2 â?? adrenoreceptor agonist and esmolol an ultra â?? shortâ??acting β1 â?? cardioselective adrenergic receptor blocker appear to be quite suitable to control the detrimental effects of laryngeal and tracheal stimulation. The study was conducted to compare the efficacy of dexmedetomidine and esmolol for attenuation of hemodynamic responses to laryngoscopy and intubation METHODS 200 patients of age 18–60 years, belonging to American Society of Anesthesiologists (ASA) physical state of I & II of either are posted for elective surgical procedure randomized into two groups of 100 each to receive dexmedetomidine (Group D): 1 μg / Kg in 20 mL normal saline over 10 mins, 7 min. prior to intubation and esmolol (Group E) : 1 mg / Kg over 1 min, 2 min prior to intubation. Changes in heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) any side effects associated with the drugs during the study, i.e., 15 min of intubation, were observed and statistically analysed. RESULTS A statistically significant difference (p < 0.01) between Groups D and E was observed in mean heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) during intubation, 1 min, 3 min, 5 min & 15 min after intubation. CONCLUSIONS Dexmedetomidine was better as compared to esmolol in attenuation of hemodynamic response to laryngoscopy and tracheal intubation.
