COMPARATIVE STUDY TO EVALUATE LIPID-LOWERING EFFECT OF FENOFIBRATE VERSUS ATORVASTATIN IN PATIENTS WITH HYPERTRIGLYCERIDAEMIA
BACKGROUND
Dyslipidaemia is a widely established risk factor for coronary artery disease. As Asians differ in pattern of various lipid abnormalities than non-Asians, this study was undertaken to compare efficacy of commonly administrated drugs, atorvastatin and fenofibrate.
MATERIALS AND METHODS
The present study was carried out in 100 diagnosed cases of hypertriglyceridaemia divided into two groups, A and B. The mean, standard deviation, standard error of mean and t value were calculated following 12 weeks of therapy of atorvastatin 10 mg in group A and micronized fenofibrate in group B.
RESULTS
Our study showed that fenofibrate is more efficacious in reducing the levels of triglycerides and rising level of HDL cholesterol, while atorvastatin is more efficacious in reducing LDL cholesterol.
CONCLUSION
Micronized fenofibrate has more efficiency in reducing triglycerides and raising HDL. Atorvastatin is more efficacious in reducing LDL levels.
KEYWORDS
Dyslipidaemia, Atorvastatin, Fenofibrate.
