Velusamy Premchandar1, Prasanthkumar Munuhur Srinivasan2, Mushahida Shaik3
BACKGROUND
Haemodynamic changes that occur during direct laryngoscopy and intubation is a major concern for the managing anaesthesiologist. Various drugs have been used to attenuate this response.
The aim of the study is to compare the efficacy of IV clonidine and IV dexmedetomidine in attenuating the haemodynamic responses to laryngoscopy and endotracheal intubation during general anaesthesia.
MATERIALS AND METHODS
100 patients who were scheduled for various elective surgeries under general anaesthesia requiring direct laryngoscopy and endotracheal intubation were included in the study. The patient’s age was varying between 18 to 60 years. After recording, the baseline parameters, patient received dexmedetomidine 1 mcg/kg or clonidine 2 mcg/kg based on the random allocation of groups by computer generated randomisation table number. Their haemodynamic changes were monitored.
RESULTS
In the present study, dexmedetomidine group had lower heart rate than that of clonidine group at different time intervals with a p value of <0.05. In clonidine group, the blood pressures were lower than that of dexmedetomidine group at different time intervals with p value of <0.05.
CONCLUSION
In this present study, dexmedetomidine at 1 mcg/kg attenuated the stress response to laryngoscopy and intubation as effectively as clonidine at 2 mcg/kg with better control of heart rate and systolic blood pressure with less hypotensive episodes.
