Dr. Sayyid Mohammed Khilar,
BACKGROUND Ventricular function is the best predictor of death after an acute coronary syndrome. It serves as a marker of myocardial damage, provides information on systolic function as well as diagnosis and the prognosis. The aim of the study is to relate cardiac troponin I with left ventricular dysfunction in acute Myocardial Infarction. MATERIALS AND METHODS This was a prospective observational study on 80 patients, aged between 20-80 years who were diagnosed with acute MI. Patient details, detailed history, and clinical features along with investigation report. RESULTS Overall, the 80 participants of the study had a mean age of 60 years. 17.5% of the cases were <50 years while the majority (82.5 %) were above 50 years of age. 67.5% were males and 32.5% were females. 59 patients (73.75%) had diabetes mellitus, 44(55%) had hypertension, 33(41.25%) gave history of alcohol consumption and 29 (36.25%) gave history of smoking habits. The mean durations of diabetes mellitus and hypertension in these subjects were 6.42 years and 5.1 years respectively. 78 out of the 80 cases included in the study had HbA1c levels of >6.5% signifying poor glycaemic status. 52 of the subjects (65%) had dyslipidaemia. Advancing age along with prevalence of diabetes mellitus was found to have a strong correlation for developing an acute MI. The mean value of trop I at presentation was 19.47 ng/ml, at 6 hours was 23.36 ng/ml, and at 24 hours was 38.33 ng/ml. The 24-hour mean value of Trop I was significantly higher. Nearly 58% of the patients presented with anterior wall MI and the remaining with inferior wall MI. There was no difference in mean values of Trop I at 6 hours and 24 hours between patients with IWMI or AWMI. Mean value of ejection fraction was 42.45%. There was no statistically significant difference between mean values of LVEF among anterior and inferior wall MI patients. 82.25% of patients with STEMI had LV dysfunction. In our study positive predictive value of trop I was 100.
