Ankita Narendra Tamhane1, Samarth Akhilesh Shukla2, Sourya Acharya3, Kishor M. Hiwale3, Arvind S. Bhake4, Sandeep Iratwar5
BACKGROUND
There are two main types of tumours- malignant or cancerous tumours and benign tumours. Cancerous tumours can be divided into primary tumours that start within the brain and secondary tumours that have spread from somewhere else known as brain metastasis tumours. Primary CNS tumours represent 2% of estimated new cancers occurring in adults. The incidence of all adult primary brain tumours in the United States is 11.8 per 1,00,000 persons per year. Frozen Section (FS) diagnosis is a useful diagnostic technique for diagnosis of tumours of central nervous system as it guides a surgeon with appropriate therapeutic decision-making on most occasions.
MATERIALS AND METHODS
In this retrospective study, we reviewed the reports of all CNS lesions from July 2016 to August 2017 in the Department of Pathology Jawaharlal Nehru Medical College, Sawangi (M), Wardha. Specimens were received from the OT complex of Neurosurgery Department of Acharya Vinoba Bhave Rural Hospital, Sawangi (M), Wardha. A total of 30 cases were studied. The tissue was frozen in a cryostat (-25°C) and 6-7μ sections were prepared and stained with rapid Haematoxylin and Eosin (H and E). The slides were examined under a light microscope by one or more general pathologists. The same specimen along with some more resected specimen were formalin fixed, additional representative sections were taken for paraffin embedding and routine H and E staining.
RESULTS
When frozen section diagnosis was correlated with histopathological diagnosis, it was found that amongst 30 cases, 21 frozen section diagnosis correlated with the standard histopathological diagnosis, which accounted for 70% diagnosis of the total cases. The sensitivity was calculated as 70%.
CONCLUSION The final diagnoses were based on permanent sections and IHC studies. On correlation, the ‘p’ value was found to be > than 0.005, which is significant. These findings are concordant with the findings of our study.
