Gayathri B.H.1, Sahila M.2, Meera Arun3, Sravan J.S.4
BACKGROUND
Polycystic ovary syndrome (PCOS) is one of the main causes for infertility. Many
studies show that PCOS is associated with production of some inflammatory
factors like CRP and IL - 18, which has a prognostic significance in analysing the
risk of future cardiovascular diseases (CVD). American heart association (AHA) has
put forward C - reactive protein (CRP) as a clinically useful marker for risk of
cardiovascular diseases. Previous studies show an increased incidence of high
levels of CRP in PCOS patients as compared to controls. If such an association is
proved in our population, CRP can be used as an ideal marker to screen apparently
normal young PCOS women for CVD. So we wanted to assess the CRP levels in
PCOS through this study.
METHODS
This was a cross sectional study conducted in the outpatient departments of
Infertility and Gynaecology in a tertiary care hospital of South India, from 2018 to
2019. It was conducted among women of age 25 - 35 years who were diagnosed
to have PCOS according to Rotterdam’s criteria, satisfying inclusion criteria.
Women of age 25 - 35 years without PCOS were taken as comparison group. The
study was conducted in 50 PCOS women and 50 women without PCOS were taken
as comparison group. Data was obtained with the help of appropriate
questionnaire and laboratory investigations. CRP level was assessed by
Immunoturbidimetric method.
RESULTS
CRP was found to be significantly elevated (P < 0.01) in PCOS (1.87 ± 2.16) when
compared to women without PCOS (0.16 ± 0.4).
CONCLUSIONS
CRP levels were significantly higher in PCOS women as compared to women
without PCOS. Thus CRP can be used as tool to assess inflammatory state in PCOS.
