Sangamesh B. Kunakeri, Mazhar M. Haq
PURPOSE To compare the efficacy of two different doses of labetalol for attenuation of haemodynamic response during laryngoscopy and endotracheal intubation - A randomised control trail. MATERIALS AND METHODS 90 patients of either sex, aged 18–60 years, of ASA (American Society of Anaesthesiologist) class I or II, posted for elective surgical procedures requiring general anaesthesia with intubation were selected. Patients were randomly allocated to any of the three groups (30 each). In Group C, i.e. control group, 5 mL 0.9% saline; in Group L1, Inj. Labetalol 0.1 mg/kg diluted with 0.9% saline with total volume of 5 mL; and in Group L2, Inj. Labetalol 0.2 mg/kg was diluted with 0.9% saline with total volume of 5 mL. The study drug was administered to subjects intravenously 5 min. prior to intubation. All the patients were subjected to the same standard anaesthetic technique. The vital parameters i.e. heart rate, systolic blood pressure and diastolic blood pressure were recorded, mean arterial pressure was calculated prior to induction at time of intubation and 1 min., 3 min., 5 min., and 10 min. after intubation. RESULTS A significant attenuation response of haemodynamics was seen in group L1 and L2 when compared to control group C. No significant difference was observed between the group L1 and L2 at intubation, 1 min., 3 min., 5 min. and 10 min. postintubation. CONCLUSION Both doses of Inj. Labetalol (0.1 mg/kg and 0.2 mg/kg) attenuate haemodynamic response to laryngoscopy and intubation in dose dependent manner.
