Pooja Parteek1, Manish Chandey2, Satya Nayyar3, Poonam Verma4, Raminder Singh5
BACKGROUND
World Health Organization (WHO) defines stroke as “rapidly developing clinical
signs of focal (or global) disturbance of cerebral function, lasting more than 24
hours or leading to death, with no apparent cause other than that of vascular
origin.” Low serum 25 hydroxy vitamin D is associated with large infarct volume,
which worsens the outcome in ischemic stroke patients. In this study, we wanted
to evaluate serum vitamin D levels in acute ischaemic stroke (AIS) patients and
correlate the severity of stroke with lipid profile & central nervous system (CNS).
METHODS
It was a cross sectional comparative study, conducted in Department of Medicine
in SGRDIMSR, Sri Amritsar from December 2018 to June 2020. A total of 100
subjects, 50 cases of AIS, diagnosed by history, clinical examination and supported
by magnetic resonance imaging (MRI) of brain and 50 age and sex matched
healthy controls were enrolled for the present study to estimate serum vitamin D
level in AIS. Detailed clinical history and clinical examination were done on all
participating subjects and relevant investigations were done. Diagnosis was
confirmed by MRI brain in acute ischemic stroke cases. The severity of neurological
impairment was evaluated as per Canadian neurological stroke scale within 24
hours of admission of the cases.
RESULTS
Mean age of cases was 62.06 ± 10.52 years and mean age of control was 59.14
± 11.36 with maximum number of subjects were in age group of 61 - 70 years.
The mean value of vitamin D in study group was 19.31 ± 9.24 while in control
group, mean value was 36.42 ± 8.33, showing more serum vitamin D deficiency
in cases having AIS than controls. (P value 0.021).
CONCLUSIONS
The present study suggests that the low serum vitamin D levels in the body is
associated with more severe neurological deficit.
