D. Nehru1, S. Vetrivel2, V. P. Kannan3
BACKGROUND
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a multisystem disorder characterised by multiple, bilateral renal cysts associated with cysts in other organs. Non-cystic manifestations of ADPKD involve cardiac valvular abnormalities also, which supports the hypothesis that a defect in extracellular matrix is the basic pathology. The aim of the study is to find out the prevalence of cardiac valvular abnormalities in patients with ADPKD.
MATERIALS AND METHODS
This was a cross-sectional study conducted in 50 patients admitted with ADPKD over a period of one year in Thanjavur Medical College Hospital. M-mode, 2D echo and Doppler were used to study the valvular abnormalities.
RESULTS
Out of 50 patients with ADPKD (males- 70% and females- 30%), 24% had MVPS, 36% had MR, 20% had AR and 16% had TR.
CONCLUSION
Echocardiography is easily performed, noninvasive, safe, reproducible and accurate in assessment of cardiac function in ADPKD. Echocardiographically detectable concentric left ventricular hypertrophy and valvular abnormalities were present in asymptomatic patients. Hence, this necessitates screening of patients without cardiac symptoms for cardiac abnormalities after the diagnosis of ADPKD has been made.
