Suresh Babu Kondaveeti
BACKGROUND Polycystic ovarian syndrome (PCOS) is a highly prevalent endocrine-metabolic disorder that implies various severe consequences to female health, including alarming rates of infertility. Although its exact aetiology remains elusive, it is known to feature several hormonal disturbances including hyperandrogenemia, Insulin Resistance (IR) and hyperinsulinemia. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334071/) Hyperinsulinemia was noted in 60% to 80% of PCOS cases and plays a central role in the development of further complications. The prevalence of obesity in PCOS ranges from 48% to 85%. The aim of the study is to evaluate Glycated Albumin (GA) and HbA1c levels with Body Mass Index (BMI) in Polycystic Ovarian Syndrome (PCOS) cases. MATERIALS AND METHODS This case-control study performed at NIMS Hospital, NIMS University, Jaipur includes 60 PCOS patients and 60 age matched healthy controls of any age. Fasting venous blood samples were obtained for analysis of fasting blood glucose, GA and HbA1c. RESULTS GA and HbA1c levels are higher in cases (16 ± 2.85), (6.4 ± 020) than in controls (14 ± 0.75), (5.45 ± 0.10). Out of 60 cases, 28 are pre-diabetic range (GA < 16-18%, HbA1c 5.75 ± 6.40%), 20 are in diabetic range (GA >18%, HbA1c >6.40) and 12 are in non-diabetic range (GA <14%, HbA1c <5.8%). BMI of PCOS cases (25.45 ± 3.4 kg/m2) was significantly higher than controls (21.25 ± 2.8 kg/m2). Both GA and HbA1c shows significant correlation with BMI. CONCLUSION From the above study we concluded that BMI associated with glycemic index in PCOS.
