P. Mohanraj1, G. Anbazhagan2, S. Kalaivalli3
ABSTRACT: BACKGROUND: CVD are the major cause of mortality in patient with CKD. One of the established risk factor for cardiovascular disease is dyslipidemia. The pattern of dyslipidemia in CKD is entirely different from general population. So the study about the lipid pattern will be useful in early intervention and management of dyslipidemia in CKD. AIM OF THE STUDY: To estimate various levels of lipids in Non-Diabetic CKD stage 3 and 4. METHODS: The study was conducted in 50 patients of CKD in stage 3 and 4; 50 age and sex matched healthy individuals were selected as control. A detailed history and clinical examination were performed. Apart from routine investigations blood urea, creatinine, electrolytes and Creatinine clearance by using Cockcroft-Gault equation were measured. RESULTS AND OBSERVATION: Mean triglyceride of the study group was 197.26 mg/dl (178.18 mg/dl. control group). Statistical significance of these values was analyzed by finding out the standard error of difference between the two mean. It was 8.89. The actual difference of the mean between the two groups was 19.08, which is more than twice of standard error of difference between the two mean. So the difference in triglycerides values between the two groups is statistically significant. Similarly Mean HDL cholesterol of the study group was 34.18 mg/dl (39.48 mg/dl, Mean LDL cholesterol of the study group was 118.61(103.36) mg/dl, and mean total cholesterol of the study group was 192.24(178.48) mg/dl and all are statistically significant. CONCLUSION: Most common lipid abnormality in this study is statistically significant reduction of HDL-C level and elevation of serum triglycerides, TC and LDL-C level in patients with CKD Stage 3and 4. Most common hyperlipoproteinemia in this study is Type IV (Fredrickson classification).
