Madhusmita Acharya1, Sumitra Bhoi2, Manoj Kumar Yadav3
BACKGROUND
Prolidase, a member of the matrix metalloproteinase (MMP) family, is a cytosolic
imido dipeptidase, which specifically splits imido dipeptides with C-terminal proline
or hydroxyproline. We wanted to compare the serum levels of prolidase enzyme
activity & total antioxidant status in patients with metabolic syndrome. Increased
prolidase activity and decreased total antioxidant status may indicate critical
biological activities relevant to pathological events in metabolic syndrome (MetS),
and this activity may be a biological indicator of disease.
METHODS
This cross-sectional study was conducted in the Department of Biochemistry, Veer
Surendra Sai Institute of Medical Sciences and Research, Burla. Out of a total of
135 subjects, 45 had metabolic syndrome, 45 were obese without metabolic
syndrome and 45 were non-obese healthy controls.
RESULTS
In MetS group, prolidase levels were significantly higher when compared to obese
and control groups (P < 0.001 and P < 0.05 respectively) and also in obese group
against control group (P < 0.05). Tacrolimus (TAC) levels were also lesser in MetS
and obese groups when compared to those of control group (P < 0.001 and P <
0.05 respectively). Prolidase was negatively correlated with TAC and high density
lipoprotein (HDL-C); r = − 0.33, P < 0.1; r = − 0.35, p < 0.08 and positively
correlated with body mass index (BMI), waist circumference, systolic blood
pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), total cholesterol
(TC), low density lipoprotein (LDL-C) & TOS (r = 0.42, P = 0.03; r = 0.39 P =
0.05; r = 0.40 P < 0.04; r = +0.44, P = 0.02; r = 0.39, P = 0.05; r = 0.41, P =
0.04 and r = 0.4, P = 0.04, respectively.
CONCLUSIONS
Increased prolidase activity is closely associated with the medical phenotype of
the metabolic syndrome. Increased prolidase activity and decreased total
antioxidant status may indicate critical biological activities relevant to pathological
events in Mets, and this activity may be a biological indicator of disease.
