Hisanath Beegum1, Prasantha Kumar Thankappan2, Mohanan Peruntharamolel Pappuni3
BACKGROUND
T
he aim of the study is t o study the spectrum of h a ematological manifestations and CD4 counts and evaluate the relationship
between h a ematological manifestations and CD4 counts in relation to WHO clinical staging in a hospital based study of HIV
infected adults in and around Kottayam.
MATERIALS AND METHODS
Clinical and h
a ematological profile of patients attending medicine department and antiretroviral therapy clinic Kottayam were
recorded. The relationsh ip between WHO clinical staging and CD4 counts and various h a ematological manifestations was
analysed.
RESULTS
A total of 120 HIV infected individuals, in which
71 were males and 49 were females . C andidiasis was most common
opportunistic infection followed by tuberculosis. Anaemia and elevated ESR was most common h a ematological abnormality.
An a emia ( Pearson correlation 0.827), ESR ( Pearson correlation +0.78), total lymphocyte count ( Pearson correla tion 0.807),
CD4 counts ( Pearson correlation 0.944) were correlating with WHO clinical staging and falling tendency of these parameters
were statistically significant but total count and platelet count had no correlation with WHO clinical staging or fal ling tendency
were not correlating with progression of disease.
CONCLUSION
Anaemia
, elevated ESR was the most common h a ematological manifestation. CD4 count total lymphocyte count can be used
to asses s the progression of disease in HIV patients. C D 4 count is best indicator of disease progression.
