Basavaraj Devendrappa Baligar1, Uday Subhash Bande2, Basith Lateef Kardkal3, Ishwar Sidappa Hasabi4, Shivappa Basavaraj Anurshetru5
BACKGROUND
To investigate relationship between glycated haemoglobin (HbA1c) level and coronary artery disease (CAD) severity.
METHODS
This cross sectional observational study was conducted over a period of six months, and 100 participants were enrolled and baseline characteristics were collected. Clinical presentations in terms of unstable angina, NSTEMI or acute myocardial infarction were diagnosed. Coronary angiography was performed on all participants to figure out the numbers of coronary artery stenosis in terms of non-significant stenosis (<50% stenosis), single or multiple vessels stenosis (≥50% stenosis). All participants were divided into subgroups according to two categories in terms of severity of clinical presentation (unstable angina, NSTEMI or acute myocardial infarction) and the number of coronary artery stenoses (single, and multiple vessels). Primary endpoint was to evaluate relationship between baseline HbA1c value and CAD severity.
RESULTS
Consistent to previous studies, participants with CAD had more risk factors such as age, smoking, low HDL-C. Notably, HbA1c level was more prominent in CAD group than that without CAD. As compared to unstable angina subgroup, HbA1c levels were gradually increased in NSTEMI and acute myocardial infarction groups. Similar trend was identified in another category in terms of higher HbA1c level corresponding to multivessel stenosis. Multivariate regression analyses showed that after adjusting for traditional risk factors as well as fasting blood glucose, HbA1c remained strongly associated with the severity of CAD.
CONCLUSION
HbA1c may be a useful indicator for CAD risk evaluation.
