Sankha Simlai1 , Pradeep Kumar2 , Tapan Kumar Mohapatra3 , Preeti Sharma4
BACKGROUND Dyslipidaemia is a common trait in subclinical (S.H.T.) and overt (O.H.T.) hypothyroidism and had been comprehensively studied; the association of dyslipidaemia, peroxidation of lipids, and coronary lipid risk factors have not been well-thought-out in sub-clinical and clinical hypothyroidism in contrast to controls. The intend of our study was to estimate lipid profile, coronary lipid risk factors, lipid peroxidation index, and malondialdehyde (M.D.A.). Our intension is also to determine their associations with TSH, thyroid hormone (fT3, fT4), and B.M.I. in hypothyroid patients. METHODS This is a case control study conducted among 176 OHT patients, 176 SHT patients, and 176 healthy controls from OPD of the medical college. RESULTS It was observed that all lipid parameters were higher in O.H.T. patients when measured against controls (p < 0.05). Similarly, the parameters were also high in the S.H.T patients group compared to euthyroid controls (p < 0.05). HDL-C was low in both hypothyroid groups when evaluated against controls (p < 0.05). Coronary lipid risk factors and levels of serum M.D.A. were also seen to be high in both hypothyroid patient groups (p < 0 .05). FT3 and FT4 were correlated with TC (p = < 0.05) and (p < 0.05) respectively and with non-HDL-C (p < 0.05) and correspondingly (r = - 0.34, p < 0.05) in OHT subjects. TC (p < 0.05), LDL-C (p < 0.05), Non-HDL-C (p < 0.05), LDL-C / HDL-C (p < 0.05) and MDA (p < 0.01) were correlated with TSH. After nullification with B.M.I., M.D.A.'s relation to LDLC / HDL-C along with TC / HDL-C ratios constantly continued although similarity between M.D.A. and LDL-C had been lost. If the function of M.D.A. was cancelled, B.M.I. correlations with T.G., T.C., and VLDL-C remained constant along with the correlation with atherogenic lipid factors and atherogenic index (A.I.) whereas the B.M.I. and LDL-C link had been lost. No associations were observed in patients with S.H.T however. CONCLUSIONS Dyslipidaemia, coronary lipid risk factors, and peroxidation of lipids were more distinct in overt hypothyroids than in the sub-clinical group.
